The Nuclear Lamina Is Composed Of Lamin Proteins

The nuclear lamina is a multi protein lattice composed of a and b type lamins and their associated proteins.

The nuclear lamina is composed of lamin proteins.

Lamins are present in all animals but are not found in microorganisms. The nuclear lamina is a structure near the inner nuclear membrane and the peripheral chromatin. Following modifications by ftase rce1 and icmt prelamin a undergoes a farnesylation dependent proteolytic cleavage catalyzed by the zinc metalloprotease zmpste24. This protein lattice associates with heterochromatin and integral inner nuclear membrane proteins providing links among the genome nucleoskeleton and cytoskeleton.

Composed of lamins and lamin associated proteins which include emerin and lbr among others 7 8 the 10 30 nm thick nuclear lamina is found ubiquitously in differentiated cells. The increasing number of proteins that interact with lamins and the compound interactions between t. Lamin b was one of the first proteins shown to be modified by prenylation 89. The nuclear lamina is a multi protein lattice composed of a and b type lamins and their associated proteins.

This protein lattice associates with heterochromatin and integral inner nuclear membrane proteins providing links among the genome nucleoskeleton and cytoskeleton. The nuclear lamina consists of two components lamins and nuclear lamin associated membrane proteins. Lamins also known as nuclear lamins are fibrous proteins in type v intermediate filaments providing structural function and transcriptional regulation in the cell nucleus. Nuclear lamins interact with inner nuclear membrane proteins to form the nuclear lamina on the interior of the nuclear envelope.

Lamin a is also farnesylated but it is unique among farnesylated human proteins 90. Lamins have elastic and mechanosensitive properties and can alter gene regulation in a feedback response to mechanical cues. The lamins are type v intermediate filaments which can be categorized as either a type lamin a c or b type lamin b 1 b 2 according to homology of their dna sequences biochemical properties and cellular localization during the cell cycle.